大鼠、小鼠自動(dòng)活動(dòng)跑輪，提供了一種簡(jiǎn)單方便的方法來(lái)測(cè)量大鼠、小鼠在長(zhǎng)時(shí)間活動(dòng)中對(duì)化學(xué)或環(huán)境刺激的反應(yīng)。

可連接到52600數(shù)據(jù)接口和加裝ANYmaze行為學(xué)分析軟件，實(shí)現(xiàn)對(duì)晝夜節(jié)律或運(yùn)動(dòng)功能等方面的研究。

型號(hào)：1800（大鼠型）、1850（小鼠型）

產(chǎn)品特點(diǎn)

· 適用于大鼠和小鼠 
· 易于監(jiān)控：兼容多種何數(shù)據(jù)采集系統(tǒng) 
· 透明的聚碳酸酯籠子，具有的可見(jiàn)性 
· 全不銹鋼車(chē)輪結(jié)構(gòu)，便于維護(hù)

· 可獨(dú)立工作，也可連接電腦

· 可選配打印機(jī)，具有內(nèi)部存儲(chǔ)和電腦軟件

· 易于監(jiān)測(cè)，易于維護(hù)，多功能接口可同時(shí)連接12只籠子

1850型小鼠自動(dòng)活動(dòng)跑輪 

· 11850型小鼠跑輪采用經(jīng)典的25cm直徑，由不銹鋼制成，配有低摩擦特氟隆襯套，運(yùn)作非常平穩(wěn)；

· 小鼠在2mm直徑的桿上自由跑到，桿子間隔7mm； 

· 跑輪裝在一個(gè)透明的聚碳酸酯籠子里，不銹鋼金屬蓋和含U型顆粒料斗的專用蓋鎖； 
· 小鼠活動(dòng)籠尺寸：37(h)x26(w)x35(d)cm；

1800型大鼠自主活動(dòng)跑輪
· 大鼠跑輪的直徑為35cm，桿子直徑為2mm，桿子的間距為8.8 mm； 
· 大鼠籠尺寸：48(h)x32(w)x47(d)cm；

轉(zhuǎn)數(shù)計(jì)數(shù)器 
· 大鼠和小鼠活動(dòng)籠配有磁性開(kāi)關(guān)和LCD計(jì)數(shù)器，可統(tǒng)計(jì)轉(zhuǎn)輪累計(jì)轉(zhuǎn)數(shù)；

· 根據(jù)需要，還可以選擇不帶計(jì)數(shù)器的1800-S大鼠自動(dòng)活動(dòng)跑輪和1850-S型小鼠自主活動(dòng)跑輪

· 使用數(shù)據(jù)線與軟件在電腦端進(jìn)行數(shù)據(jù)收集；

數(shù)據(jù)采集 
· 配備多功能接口52600，能夠同時(shí)連接12活動(dòng)跑輪； 
· 可選配專業(yè)的分析軟件ANYmaze進(jìn)行管理，進(jìn)行分析和統(tǒng)計(jì)；

選擇52600多功能數(shù)據(jù)采集接口時(shí)，不需要計(jì)數(shù)器，這時(shí)需要選擇的型號(hào)是：1800-S型大鼠自動(dòng)活動(dòng)跑輪和1850-S型小鼠自主活動(dòng)跑輪。

大鼠活動(dòng)示意圖：

參考文獻(xiàn)：

1.Reddy, Anita et al. “pH-Gated Succinate Secretion Regulates Muscle Remodeling in Response to Exercise." Cell vol. 183,1 (2020): 62-75.e17. doi:10.1016/j.cell.2020.08.039

2.Brooks, Simon P, and Stephen B Dunnett. “Tests to assess motor phenotype in mice: a user's guide." Nature reviews. Neuroscience vol. 10,7 (2009): 519-29. doi:10.1038/nrn2652

3.Videnovic, Aleksandar et al. “'The clocks that time us'--circadian rhythms in neurodegenerative disorders." Nature reviews. Neurology vol. 10,12 (2014): 683-93. doi:10.1038/nrneurol.2014.206

4.Correia, Jorge C et al. “Muscle-secreted neurturin couples myofiber oxidative metabolism and slow motor neuron identity." Cell metabolism vol. 33,11 (2021): 2215-2230.e8. doi:10.1016/j.cmet.2021.09.003

5.Mattson, Mark P, and Thiruma V Arumugam. “Hallmarks of Brain Aging: Adaptive and Pathological Modification by Metabolic States." Cell metabolism vol. 27,6 (2018): 1176-1199. doi:10.1016/j.cmet.2018.05.011

6.Islam, Mohammad R et al. “Exercise hormone irisin is a critical regulator of cognitive function." Nature metabolism vol. 3,8 (2021): 1058-1070. doi:10.1038/s42255-021-00438-z

7.Miletta, Maria Consolata et al. “AgRP neurons control compulsive exercise and survival in an activity-based anorexia model." Nature metabolism vol. 2,11 (2020): 1204-1211. doi:10.1038/s42255-020-00300-8

8.Brigger, Daniel et al. “Eosinophils regulate adipose tissue inflammation and sustain physical and immunological fitness in old age." Nature metabolism vol. 2,8 (2020): 688-702. doi:10.1038/s42255-020-0228-3

9.van Veen, J Edward et al. “Hypothalamic estrogen receptor alpha establishes a sexually dimorphic regulatory node of energy expenditure." Nature metabolism vol. 2,4 (2020): 351-363. doi:10.1038/s42255-020-0189-6

10.Brocker, David T et al. “Optimized temporal pattern of brain stimulation designed by computational evolution." Science translational medicine vol. 9,371 (2017): eaah3532. doi:10.1126/scitranslmed.aah3532

11.Janota, Cátia Silva et al. “Shielding of actin by the endoplasmic reticulum impacts nuclear positioning." Nature communications vol. 13,1 2763. 19 May. 2022, doi:10.1038/s41467-022-30388-3

12.Bobba, Christopher M et al. “Nanoparticle delivery of microRNA-146a regulates mechanotransduction in lung macrophages and mitigates injury during mechanical ventilation." Nature communications vol. 12,1 289. 12 Jan. 2021, doi:10.1038/s41467-020-20449-w

13.Mridha, Zakir et al. “Graded recruitment of pupil-linked neuromodulation by parametric stimulation of the vagus nerve." Nature communications vol. 12,1 1539. 9 Mar. 2021, doi:10.1038/s41467-021-21730-2

14.Navas-Olive, Andrea et al. “Multimodal determinants of phase-locked dynamics across deep-superficial hippocampal sublayers during theta oscillations." Nature communications vol. 11,1 2217. 5 May. 2020, doi:10.1038/s41467-020-15840-6

15.Nohara, Kazunari et al. “Nobiletin fortifies mitochondrial respiration in skeletal muscle to promote healthy aging against metabolic challenge." Nature communications vol. 10,1 3923. 28 Aug. 2019, doi:10.1038/s41467-019-11926-y

     

    

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